2. Metabolic Enzyme/Protease NF-κB Immunology/Inflammation Membrane Transporter/Ion Channel Apoptosis
  3. PDHK Reactive Oxygen Species NKCC Apoptosis
  4. Sodium dichloroacetate

Sodium dichloroacetate  (Synonyms: 二氯乙酸钠)

目录号: HY-Y0445A 纯度: 99.76%
COA 产品使用指南

摩尔计算器

Sodium dichloroacetate 是癌细胞线粒体中的一种代谢调节剂，具有抗癌活性。Sodium dichloroacetate 抑制丙酮酸脱氢酶激酶 (PDHK)，从而导致肿瘤微环境中的乳酸减少。Sodium dichloroacetate 增加活性氧 (ROS) 的产生并促进癌细胞凋亡，还可作为 NKCC 抑制剂。

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Sodium dichloroacetate Chemical Structure

Sodium dichloroacetate Chemical Structure

CAS No. : 2156-56-1

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100 mg ￥500
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500 mg ￥1500
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Customer Review

Other Forms of Sodium dichloroacetate:

Sodium dichloroacetate 相关抗体

Top Publications Citing Use of Products

    Sodium dichloroacetate purchased from MCE. Usage Cited in: Life Sciences. 2022: 121192.

    Sodium dichloroacetate (DCA; 10 mM; 48 h) significantly inhibits hypoxia-induced proliferation of HPASMCs (Fig I) , and markedly increases the apoptosis rate (Fig J).

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Sodium dichloroacetate is a metabolic regulator in cancer cells' mitochondria with anticancer activity. Sodium dichloroacetate inhibits PDHK, resulting in decreased lactic acid in the tumor microenvironment. Sodium dichloroacetate increases reactive oxygen species (ROS) generation and promotes cancer cell apoptosis. Sodium dichloroacetate also works as NKCC inhibitor[1].

    IC50 & Target

    PDHK; Reactive oxygen species (ROS); Apoptosis; NKCC[1]
    体外研究
    (In Vitro)

    Sodium dichloroacetate increases ROS generation in mitochondria. Sodium dichloroacetate affects cell growth and viability through the ROS production increase derived from the promotion of oxidative metabolism. The effects of Sodium dichloroacetate on multiple myeloma cell viability, cell cycle arrest, and apoptotic cell death were associated with pyruvate dehydrogenase kinases (PDK) inhibition, restored pyruvate dehydrogenase (PDH) activity, and the promotion of oxidative metabolism in association with increased intracellular ROS production which depends on the Sodium dichloroacetate dose. The Sodium dichloroacetate effects cooperated with C I inhibition promoting the oxidative stress in rat VM-M3 glioblastoma cells. Increased ROS levels in Sodium dichloroacetate-treated cancer cells are related to the induction of apoptosis associated with the increased cytochrome c expression. Sodium dichloroacetate causes ROS-dependent T-cell differentiation[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Sodium dichloroacetate 相关抗体:
    体内研究
    (In Vivo)

    The NKCC1 RNA expression levels in Sodium dichloroacetate-treated gonad-intact and castrated males are significantly decreased, and no such effect is determined in the gonad-intact and castrated female Sodium dichloroacetate-treated rats[1].
    A single Sodium dichloroacetate dose causes a significantly higher 24 h diuresis in Wistar male rats, and the increased diuresis is related to NKCC2 inhibition. The NKCC2 is more abundant in kidneys of intact females compared to intact males, with a greater transporter density in Sprague-Dawley female rats[1].
    The oral Sodium dichloroacetate bioavailability in naïve male rats dosed 5, 20 and 100 mg/kg is significantly lower than in GSTζ-depleted ones (10%, 13%, 81% and 31%, 75%, 100%, respectively). The liver extraction of Sodium dichloroacetate in the GSTζ-depleted rats has linear kinetics, but it decreases with the metabolism saturation at higher doses[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    Clinical Trial
    分子量

    150.92

    Formula

    C2HCl2NaO2
    CAS 号
    性状

    固体

    颜色

    White to off-white

    中文名称

    二氯乙酸钠
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    溶解性数据
    细胞实验： 

    H2O 中的溶解度 : 100 mg/mL (662.60 mM; 超声助溶)

    DMSO 中的溶解度 : 25 mg/mL (165.65 mM; 超声助溶 (<60°C); 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

    配制储备液
    浓度 溶剂体积 质量 1 mg 5 mg 10 mg
    1 mM 6.6260 mL 33.1301 mL 66.2603 mL
    5 mM 1.3252 mL 6.6260 mL 13.2521 mL
    查看完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
    储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

    * 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

    • 摩尔计算器

    • 稀释计算器

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    质量
    =
    浓度
    ×
    体积
    ×
    分子量 *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start)

    C1

    ×
    体积 (start)

    V1

    =
    浓度 (final)

    C2

    ×
    体积 (final)

    V2

    动物实验：

    以下溶解方案，请直接配制工作液。建议现用现配，在短期内尽快用完。 以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比； 如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶。

    • 方案 一

      请依序添加每种溶剂： PBS

      Solubility: 100 mg/mL (662.60 mM); 澄清溶液; 超声助溶

    动物溶解方案计算器
    请输入动物实验的基本信息：

    给药剂量

    mg/kg

    动物的平均体重

    g

    每只动物的给药体积

    μL

    动物数量

    只
    由于实验过程有损耗，建议您多配一只动物的量
    计算结果
    工作液所需浓度 : mg/mL
    该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
    您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
    纯度 & 产品资料

    纯度: 99.76%

    COA (193 KB) HNMR (218 KB) RP-HPLC (204 KB)

    产品使用指南 (1538 KB)
    参考文献

    Sodium dichloroacetate 相关分类

    完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
    储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

    可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
    DMSO / H2O 1 mM 6.6260 mL 33.1301 mL 66.2603 mL 165.6507 mL
    5 mM 1.3252 mL 6.6260 mL 13.2521 mL 33.1301 mL
    10 mM 0.6626 mL 3.3130 mL 6.6260 mL 16.5651 mL
    15 mM 0.4417 mL 2.2087 mL 4.4174 mL 11.0434 mL
    20 mM 0.3313 mL 1.6565 mL 3.3130 mL 8.2825 mL
    25 mM 0.2650 mL 1.3252 mL 2.6504 mL 6.6260 mL
    30 mM 0.2209 mL 1.1043 mL 2.2087 mL 5.5217 mL
    40 mM 0.1657 mL 0.8283 mL 1.6565 mL 4.1413 mL
    50 mM 0.1325 mL 0.6626 mL 1.3252 mL 3.3130 mL
    60 mM 0.1104 mL 0.5522 mL 1.1043 mL 2.7608 mL
    80 mM 0.0828 mL 0.4141 mL 0.8283 mL 2.0706 mL
    100 mM 0.0663 mL 0.3313 mL 0.6626 mL 1.6565 mL

    * 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Sodium dichloroacetate2156-56-1二氯乙酸钠PDHKReactive Oxygen SpeciesNKCCApoptosisPyruvate dehydrogenase kinasePDH kinaseNa-K-Cl cotransporterNa(+)-K(+)-Cl(-) cotransporterNa+-K+-Cl− cotransporter AnticancermitochondriametabolicpyruvatedehydrogenaselacticacidROSapoptosisInhibitorinhibitorinhibit

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    目录号：
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